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Last Updated on 21st January 2022

What is the Osmotic Fragility Test used for?What is included in the Osmotic Fragility Test?Procedure for Osmotic Fragility Test How to prepare for the Osmotic Fragility Test?What types of infection can the Osmotic Fragility test detect?How much does an Osmotic Fragility Test cost?How long does it take to get the results for the Osmotic Fragility Test?What do abnormal Osmotic Fragility test results indicate?What can affect the results of the Osmotic Fragility Test?Frequently Asked Questions

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What is the Osmotic Fragility Test used for?

Two inherited disorders, thalassemia, and hereditary spherocytosis can be diagnosed with an osmotic fragility test.

Thalassemia is a condition in which your body produces an abnormal kind of haemoglobin. Haemoglobin is the oxygen-carrying protein in red blood cells. Your red blood cells are more likely to be damaged if you have thalassemia. Anaemia can happen as a result of this.

The outer layer of your red blood cells is affected by hereditary spherocytosis, which distorts their form. This causes more vulnerable red blood cells to break down more quickly, resulting in anaemia. A blood sample is required for an osmotic fragility test. The ability of your red blood cells to split apart in a salt solution will be examined. The test is positive if your red blood cells are more brittle than normal.

What is included in the Osmotic Fragility Test?

Your blood will be prepared in the lab. Your red blood cells will be introduced to liquids with varying salt concentrations to determine osmotic fragility. Normal blood cells may withstand low salt solutions better than spherocytosis or thalassemia blood cells, which are more fragile.

You most likely have inherited spherocytosis or thalassemia if your cells are frail. Hemolytic anaemia can be caused by one of these hereditary disorders. This type of anaemia develops when your red blood cells are damaged too quickly. If your osmotic fragility test is positive, you’ll need to double-check the data and see if you’re anaemic.

Procedure for Osmotic Fragility Test

Osmotic fragility test is a simple blood test that withdraws blood from your veins. It is often done in a doctor’s clinic or a laboratory. The technician will ask you to roll up one of your sleeves or remove your arm from the sleeve if you’re wearing a long-sleeved shirt.

In order to make the blood withdrawal easier, the technician will tighten an elastic strap around your upper arm. This aspect of the procedure may make you feel uneasy.

The technician will locate a vein and use an antiseptic to clean the region to draw blood using a syringe and a needle. You may feel a sting but the pain goes away almost immediately. The technician will then apply a bandage or cotton swab to stop bleeding if any.

Book an Osmotic Fragility Test to check your red blood cells level!

How to prepare for the Osmotic Fragility Test?

There is no special preparation for an osmotic fragility test ahead of time. A blood sample is obtained when the test is performed. However, you should keep the following in mind before and during the osmotic fragility-;

Before the test	During the test
Fasting is not required before taking an osmotic fragility test Wear loose and comfortable clothes before going for a test. Wear a short-sleeved shirt so that the lab technician can draw your blood easily.	A lab technician or a nurse will sanitize the area where the blood is supposed to be drawn from. When the needle is inserted into the skin, you may get a stinging sensation or a bruise may be formed, although neither should last long. The lab technician will put a bandage over it.

Things to consider after the Osmotic Fragility Test is complete

After you receive the Osmotic fragility test report, consult with your doctor about the treatment of the disorder. The doctor will interpret the results for you and will recommend the best treatment for you. Do not self diagnose your health condition and avoid taking any medications without prescriptions.

*What types of infection can the Osmotic Fragility test detect?

The purpose of this test is to detect hereditary spherocytosis and thalassemia. Red blood cells in hereditary spherocytosis and thalassemia are more brittle than normal. Since it is a hereditary disease it can be considered an infection.

How much does an Osmotic Fragility Test cost?*

The cost of the Osmotic fragility test can vary in different places but they are more or less in the same range and do not differ drastically.

City	Test Price Starting from
Book Osmotic Fragility Test Cost in Delhi	₹ 112.0
Book Osmotic Fragility Test Cost in Gurugram / Gurgaon	₹ 112.0
Book Osmotic Fragility Test Cost in Noida	₹ 112.0
Book Osmotic Fragility Test Cost in Faridabad	₹ 112.0
Book Osmotic Fragility Test Cost in Ghaziabad	₹ 112.0
Book Osmotic Fragility Test Cost in Jaipur	₹ 340.0
Book Osmotic Fragility Test Cost in Hyderabad	₹ 342.0
Book Osmotic Fragility Test Cost in Pune	₹ 405.0
Book Osmotic Fragility Test Cost in Chandigarh	₹ 700.0
Book Osmotic Fragility Test Cost in Bangalore / Bengaluru	₹ 960.0
Book Osmotic Fragility Test Cost in Chennai	₹ 960.0
Book Osmotic Fragility Test Cost in Mumbai	₹ 960.0
Book Osmotic Fragility Test Cost in Thane	₹ 960.0

*Disclaimer: The value varies based on location, time, and your preferred lab partner.

How long does it take to get the results for the Osmotic Fragility Test?

Your report will be updated on the MFine app within 48 hours after the test. After you receive the RBS test report, consult with your doctor, who’d be able to recommend the best treatment plan for you. Do not self diagnose or treat your health condition.

What do abnormal Osmotic Fragility test results indicate?

Your blood will be prepared in the lab for osmotic fragility testing, and your red blood cells will be added to solutions with various salt concentrations. Normal blood cells may withstand low salt solutions better than spherocytosis or thalassemia blood cells, which are more fragile.

Thalassemia is a blood disorder that is passed down the generations. It occurs when DNA within cells is mutated.
Hereditary spherocytosis (HS), is a condition in which red blood cells’ shells, or membranes, are fragile. The red blood cells become smaller as they move through the spleen. As a result, their lifespan is much shorter than that of normal cells.
Anaemia is a condition in which there aren’t enough red blood cells to carry enough oxygen to your body.

If your osmotic fragility test is positive, the next step is to confirm the results and test whether you are actively anaemic.

Disclaimer: Please consult with your doctor for interpreting the test reports

Is the Osmotic fragility test definitive?

An osmotic fragility test is a well-known test in medicine, having been used by doctors for more than 70 years. As it determines the fragility of red blood cells, it is regarded as a reliable method of determining the health of red blood cells. It is also a trusted method of detection of thalassemia by doctors with the most accurate and precise results and clear interpretation.

How to read the Osmotic Fragility test report?

The osmotic fragility test (OFT) is a method of determining the fragility of blood cells in varying amounts of saline solution. Normal cells, on one hand, survive the hypotonic environment(low-salt solution), whereas, on the other hand, fragile cells are not able to withstand such conditions and lysis or breaking of cells occurs.

There is no actual agreement among laboratories on a reference range of results for erythrocyte osmotic fragility.

Normal blood cells	Fragile blood cells
Remain intact in low salt solution	Blood cells swell and explode

Disclaimer: Consult your doctor for the interpretation of the results and seek help for the treatment.

Book an Osmotic Fragility Test to check your red blood cells level!

Osmotic Fragility Test at home – how does it work?

The Osmotic fragility test is a common blood test done to determine the fragility of blood cells which detects conditions like thalassemia.

A lab technician will visit your home when you book your tests through the MFine app. The lab technician will first clean your arm, sanitize it and then insert a syringe into your vein. The technician will collect the required amount of blood into a vial. The lab technician will then remove the needle and place a ball of cotton wool or a bandage over the prick.

Are there any risks involved with an Osmotic Fragility Test?

There are few hazards associated with having blood extracted. Infection is one of the threats that can happen while doing a blood withdrawal.

If your temperature rises beyond 100°F, contact your doctor. If the skin around the area where the blood was taken turns red, puffy, or painful to touch, you should seek medical attention. The skin around the area of the blood withdrawal may be bruised or sore for a few days after the test. A cold pack applied to the affected area can help to decrease bruising and discomfort. You can resume all normal activities after the test unless your doctor instructs you differently.

What can affect the results of the Osmotic Fragility Test?

The extrinsic factors include:

Ionic strength, and pH of the incubation media
The type of anticoagulant and blood storage time
Ambient temperature, drugs
Medicinal plant extracts
Xenobiotics, and chemical agents

While intrinsic factors include:

Ageing
Sex
Breed
Species
Pregnancy
Lactation
Genetic factors

Book an Osmotic Fragility Test to check your red blood cell level!

Why book an Osmotic Fragility Test?

For infants with a family history of thalassemia or hereditary spherocytosis, doctors may do osmotic fragility tests. This might be a quick and inexpensive technique to aid in the diagnosis of the disease. However, more blood tests or genetic testing may be required to confirm the issue. This is because different situations may provide comparable outcomes.
The osmotic fragility test can also be used to determine whether anaemia is caused by thalassemia or spherocytosis.

Our Trusted Lab Partners for Osmotic Fragility Test

MFine Diagnostics

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₹600

Wellness Pathcare

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₹600

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Frequently Asked Questions - FAQs

Is the lab technician coming for the Osmotic Fragility Test sample collection vaccinated?

Yes. Our lab technicians are fully vaccinated. Further, they also ensure safety throughout by wearing a mask, gloves, and frequently sanitizing themselves during the sample collection.

Does MFine provide the interpretation for the results along with the reports?

Yes, MFine provides the interpretation for the result along with the reports. You can also avail a free medical consultation with a doctor to understand your reports accurately. The doctor will also advise and prescribe medicines, if required, based on the results.

How can I download my Osmotic Fragility Test report?

Login to MFine
Go to your profile
Click on Attachment and Reports
Click on Lab Report
Download the report

Are there any discount offers running on the Osmotic Fragility test?

Usually, you can avail of up to a 50% discount on the osmotic fragility test through MFine. However, the discount and test price may vary based on lab partner and location.

Can thalassemia be prevented?

No, the solution for preventing thalassemia has not been discovered yet. Since thalassemia is hereditary, it cannot be prevented. Genetic testing can be used to identify carriers of this illness.

Is a doctor prescription required for an Osmotic Fragility Test?

Yes, a doctor’s prescription is required for an osmotic fragility test. It is an intricate measure of thalassemia and hereditary spherocytosis. The doctor may order a test to start the treatment.

Can Thalassemia be cured completely?

The only treatment for thalassemia is bone marrow and stem cell transplantation from a compatible related donor. It is the most successful treatment discovered until now in medical science. However, the availability of osmotic fragility is often debated and is considered to be available to a few patients.

What alternative can be given for an Osmotic Fragility Test?

Other techniques such as flow-cytometric assays have lately been utilized to identify HS. The eosin-5′-maleimide (EMA) and flow-cytometric osmotic fragility tests are the two types of tests (FOFT) that produced more accurate findings than a standard osmotic fragility test, according to studies