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Dr. SreelekhaLast Updated on 19th January 2022

What is a Calprotectin Test used for?What is included in a Calprotectin Test?Procedure for Calprotectin Test How to prepare for a Calprotectin Test?How long does it take to get the results of a Calprotectin Test?What do abnormal Calprotectin Test results indicate?Is calprotectin a definitive test?Calprotectin Test at home – how does it work?Are there any risks involved with the Calprotectin Test? FAQs

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What is a Calprotectin Test used for?

Faecal Calprotectin Test is used to determine bowel inflammation such as Inflammatory Bowel Diseases (IBD) like Crohn’s disease. It distinguishes between disorders of the intestines and thus makes diagnosis and treatment easier. Long-standing conditions such as Inflammatory Bowel disease, which goes undiagnosed in many individuals, can be detected through a Calprotectin Test. Monitoring disease progression and treatment efficacy are other useful indications.

Your doctor may recommend you a Calprotectin Test if you suffer from the following symptoms:

Diarrhoea or loose motion, which may be watery or, in some cases, blood-stained.
Stomach aches in regular intervals.
You may experience weight loss which cannot be explained by any other reason.
Feeling of cramps
Bloating
Bleeding from your rectum or anus.

Symptoms may not always be the same as mentioned above, and therefore, one should not self-diagnose or treat themselves at home.

What is included in a Calprotectin Test?

The amount of calprotectin present in the stool is measured by this test.

Calprotectin is a protein that is produced and released by White Blood Cells (WBCs) called Neutrophils and Monocytes present in our blood. Whenever a tissue or part of our body is under attack by an infection, our immune system tries to defend it by sending Neutrophils through the blood.

These neutrophils act by releasing certain substances, important among them being calprotectin, helping to fight and bring down inflammation.

Long-standing infection like in Chronic inflammatory bowel disease, these calprotectin levels may rise substantially.
Sometimes the levels of calprotectin may be low in non-inflammatory conditions of the intestines like IBS.

Thus, calprotectin helps control the infection and is a useful indicator of your bowel or intestinal health.

When there is inflammation or one that does not resolve, it may cause the calprotectin levels to rise substantially over a period of time, which is known as chronic inflammation.

Research says that the sensitivity of a Fecal Calprotectin Test has improved over the years and thus has proved beneficial for Gastroenterologists around the world in managing intestinal conditions.

Procedure for Calprotectin Test

Stool samples will be collected with the help of a collection device and sent to a designated laboratory by our lab technicians. This device helps prevent contamination from environmental and personal substances.
The assigned laboratory will analyze the stool sample for calprotectin levels with the help of an ELISA test or Enzyme-Linked Immunosorbent Assay.
ELISA is a gold-standard test that uses an antibody that binds to the intended substances (in this case, calprotectin) to determine the level of calprotectin in your stool.
It is a highly sensitive tool that minimizes errors in detecting the levels of calprotectin.
An ELISA test result will provide you with the amount of calprotectin present in your intestines.

Book a Calprotectin Test to check your calprotectin level!

How to prepare for a Calprotectin Test?

A few important precautions and preparations must be taken before giving your stool samples for testing.

You must inform your Physician or Gastroenterologist about any existing medicine that you may be taking. After the proper screening, your doctor will advise you to go for a Calprotectin Test with a proper prescription.
Certain foods and beverage intake may need to be reduced, stopped, or modified, like Nicotine products, Alcoholic beverages, and medicines like Non-Steroidal Anti-inflammatory Drugs (NSAIDs).
One should wear clean disposable gloves while providing a stool sample, thus preventing contamination of the sample.
The container must be held close to your anus to collect the stool properly.
Gloves should be disposed of once a sample is collected.

Things to consider after a Calprotectin Test is complete

Your stool sample will be sent to the designated lab.
It may take a few days for results.
After results for the Calprotectin Test are obtained, you must consult a physician or Gastroenterologist for further treatment. Self-interpretation may prove hazardous.
Your doctor may recommend if further testing is required based on the results of the Calprotectin Test.

How much does a Calprotectin Test cost?

Approximate cost of a Fecal Calprotectin Test in India.

Sr. No	City	Approximate cost
1.	Book Calprotectin Test in Delhi	Rs. 2250/-
2.	Book Calprotectin Test in Hyderabad	Rs. 2338/-
3.	Book Calprotectin Test in Kolkata	Rs. 2338/-
4.	Book Calprotectin Test in Pune	Rs. 2338/-
5.	Book Calprotectin Test in Mumbai	Rs. 2338/-

How long does it take to get the results of a Calprotectin Test?

You can expect to get the results for the Calprotectin Test within 24 to 48 hours after the sample is collected. However, in certain cases, depending on the location, medical advice, and preferred lab partner, it may take longer.

What do abnormal Calprotectin Test results indicate?

Faecal calprotectin level may help you find out the possible causes of your symptoms.

Some bacterial infections may cause a significant and sometimes transient rise in the calprotectin levels in your stool, whereas, on the other hand, viral infections may cause only slight elevation.

High levels: Usually indicate long-standing diseases such as Inflammatory bowel disease (IBD), Colorectal cancer, Colitis. It may also provide an insight into the acute exacerbation of an underlying disease. Further, testing such as colonoscopy may be advised by your doctor.
Normal to low levels: This may be nothing to worry about much, and your doctor may advise lifestyle changes, dietary modifications to improve symptoms. A lower than normal level of calprotectin in the stool may point towards a non-inflammatory disease of the large intestine such as Irritable Bowel Syndrome (IBS).
Moderate levels: Borderline elevated levels may point towards initial stages of inflammation or bacterial infection, which may require further testing.

Is calprotectin a definitive test?

Faecal calprotectin level is useful in determining an intestinal condition but may not always prove to be a definitive test.

calprotectin levels are indicators of abnormalities in your intestines. They are not useful when a condition exists in your small intestine or other areas of the lower abdomen.

They may provide false-positive results when some other underlying inflammatory condition somewhere else in the body abnormally elevates the calprotectin levels like Cancer, Ulcers, and parasitic infections. Normal calprotectin levels do not mean the absence of IBD.

How to read the Calprotectin Test report?

All laboratory tests are provided with a reference range of the substance intended to be reported as normal or abnormal.

According to the York care pathway, the following reference range is provided for interpretation.

Sr. No	Test result value	Interpretation
1.	<100µg/g	Normal or low
2.	100 – 250µg/g	Moderately elevated
3.	>250µg/g	High

The values provided are recorded as µg/g read as micrograms per gram of a stool sample, which is the standard unit of measurement for calprotectin levels. The reference range may vary according to different labs and criteria used by doctors.

Book a Calprotectin Test to check your calprotectin level!

Calprotectin Test at home – how does it work?

The Calprotectin Test is just like any other blood test. A lab technician visits your home when you book your tests through the MFine app. The lab technician first prepares you for the test by wearing sterile gloves himself and will provide you with one as well. The required amount of stool sample is collected with a special container and is stored properly in a transport device. Recent trends have also provided a phone-based app that, if appropriate, can interpret results at your home.

Are there any risks involved with the Calprotectin Test?

During sample collection, a minor chance of contamination does exist, which adds up to diagnostic errors and the risk of misdiagnosis and/or treatment.

The Fecal Calprotectin Test may not detect conditions apart from the ones directly affecting the large intestine. Some Inflammatory conditions and cancers of the small intestine may go undiagnosed and need a high suspicion and diagnostic accuracy.

There is also a possibility of having low levels of calprotectin in your stool, and you still may have symptoms of Inflammatory Bowel Disease, which may be hazardous in some situations.

What can affect the results of a Calprotectin Test?

Normal or low levels of calprotectin in your stool may sometimes indicate that the inflammation has subsided, which means you are probably in a remission phase of long-standing bowel disease.

Any other underlying disease in the body may abnormally elevate your calprotectin levels, such as celiac disease, allergies, or intolerance to certain substances in the body. The symptoms of the above-mentioned conditions mimic any bowel disease, and thus it is important to rule out other conditions.

Book a Calprotectin Test to check your calprotectin level!

Why book a Calprotectin Test?

The diagnostic accuracy of a Fecal Calprotectin Test is more than other serological tests such as blood CRP and ESR levels.
They provide good distinguishing results between many conditions of the intestine.
Patients are reassured of their treatment and disease prognosis, which greatly impacts their financial security.
The financial burden of intestinal conditions on society makes it particularly desirable to have an accurate and early diagnosis.
Referrals for further testing and endoscopy are reduced to a great extent which helps doctors in primary care hospitals prevent further complications.
Improved Patient care is the greatest benefit offered by this test.

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Frequently Asked Questions - FAQs

Is the lab technician coming for Calprotectin Test sample collection vaccinated?

Yes. Our lab technicians are fully vaccinated. Further, they also ensure safety throughout by wearing a mask, gloves and frequently sanitizing themselves during the sample collection.

Does MFine provide the interpretation for the results along with the reports?

Yes, MFine provides the interpretation for the result along with the reports. You can also avail a free medical consultation with a doctor to understand your reports accurately. The doctor will also advise and prescribe medicines, if required, based on the results.

How can I download my Calprotectin Test report?

Login to MFine
Go to your profile
Click on Attachment and Reports
Click on Lab Report
Download the report

Are there any discount offers running on the Calprotectin Test?

Usually, you can avail yourself of up to a 50% discount on the Calprotectin Test through MFine. However, the discount and test price may vary based on lab partner and location.

What are the symptoms associated with inflammatory bowel disease?

Inflammatory bowel disease symptoms can depend on location or the severity of the inflammation, but the body may show the following general symptoms- fatigue, Altered bowel habits, which can be constipation or diarrhoea, stomach pain, blood in stool, loss of appetite, unexplained weight loss, etc.

Can a blood sample be utilized instead of a stool sample for detecting calprotectin?

No blood sample detects other sources of inflammation such as ESR and CRP. A stool sample provides accurate information on intestinal inflammation. It provides a direct correlation between your symptoms and intestinal health and therefore is much more reliable.

Can I get this test done at my doctor's clinic?

Calprotectin Test requires exclusive stool testing that is performed only at specialized laboratories. The stool sample is usually sent to reference labs and may take a few hours to days for test results.

You can book a test on the MFine app and get it done at the convenience of your home.

I have a high calprotectin level. What should I do next?

High calprotectin levels may indicate some abnormalities that should be confirmed with your physician and/or Gastroenterologist. Please do not do self-diagnosis and treatment, which may prove hazardous. Your doctor will prescribe further tests or start you on medications that will help you reduce calprotectin levels.

How can I reduce my calprotectin levels?

Reducing calprotectin levels may depend on the cause of the rise. If there is an underlying infection in your intestines, resolving the source of infection may help reduce calprotectin levels. If it is due to Inflammatory bowel disease, then medication may be prescribed to you, which helps in healing.

Dietary and lifestyle changes as recommended by your physician or Gastroenterologist may reduce levels and other associated symptoms.