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Triple Marker Test

Dr.Nikit MahaleLast Updated on 20th January 2022

A Triple marker test is a blood test that is performed during pregnancy as a screening test in conjunction with other tests. It does not provide a diagnosis; rather, it just indicates whether the infant has any potential genetic problems. To diagnose the suspected anomaly, more tests and medical consultations are required. Screening implies that the triple marker test report takes into account the pregnant woman's age, weight, ethnicity, pre-existing ailments, type of pregnancy (multiple, twins), and so on to identify the risk of these anomalies in the newborn.

What is the Triple Marker Test used for?What is included in the Triple Marker Test?Procedure for Triple Marker Test How to prepare for the Triple Marker Test?What conditions can the Triple Marker Test detect?How much does the Triple Marker Test cost?How long does it take to get the results for the Triple Marker Test?What do abnormal Triple Marker Test results indicate?Why to book a Triple Marker Test?Frequently asked questions

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What is the Triple Marker Test used for?

A triple marker screen test analyses a blood sample for the presence of AFP, HCG, and estriol.

AFP is a protein made by the fetus. High levels of this protein may signal potential abnormalities such as neural tube malformations or the inability of the fetus’s abdomen to close.
The placenta produces HCG, which is a hormone. Low levels may suggest an issue with the pregnancy, such as a miscarriage or an ectopic pregnancy. A molar pregnancy, or multiple pregnancies with two or more children, might be indicated by high HCG levels.
Estriol is an estrogen produced by both the fetus and the placenta. Low estriol levels, especially when combined with low AFP and high HCG levels, may suggest a higher risk of conceiving a baby with Down syndrome.

What is included in the Triple Marker Test?

For many years, pregnant women have had access to the Triple Test, which can offer you and your doctor vital information about your pregnancy. When used in conjunction with diagnostic methods such as ultrasonography and amniocentesis (examination of amniotic fluid which is a bag of water surrounding the baby), MSAFP (Maternal serum AFP) can detect up to 85 percent of open neural tube abnormalities. Abnormal Triple Test findings, followed by ultrasound and amniocentesis, may detect 60 to 70% of Down syndrome pregnancies and many Trisomy 18 pregnancies. In addition to providing information about potential neural tube defects, Down syndrome, and Trisomy 18, the Triple Test may help to identify twins, detect additional abnormalities, and warn your doctor of elevated risks for other pregnancy issues.

Procedure for Triple Marker Test

The triple marker screen test is performed in a hospital, clinic, doctor’s office, or laboratory. The procedure is comparable to that of any other blood test.

Step 1: The technician will first instruct you to extend your arm and make a fist. This will aid him in locating your vein.

Step 2: The doctor will next wrap a strap over the patient’s arm and firmly secure this area.

Step 3: The technician will next use an antibacterial and antiseptic wipe to clean the area.

Step 4: A needle attached to a vial used for blood storage will then be inserted.

Step 5: Once the vial is full, the technician will remove it and wipe the region with an antiseptic and antibacterial swab.

Step 6: The blood sample will then be submitted to a facility for analysis, where a biochemist will assess it.

Step 7: The results will then be entered into the software and transmitted to the doctor. The doctor will then inform you of the outcome.

The triple marker screen tests have no negative effects. You may feel some discomfort as a result of the needle used to draw blood, but this will pass rapidly.

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How to prepare for the Triple Marker Test?

The triple pregnancy test is a risk-free test. This test does not necessitate any particular eating, drinking, or other preparation on the part of the female subject prior to the procedure hour.

Things to consider after the Triple Marker Test is complete

Additional screening tests may be used by certain parents in order to better comprehend the diagnosis or to obtain a second opinion. Prenatal ultrasounds, for example, can assist parents to confirm a diagnosis. Consult your primary care physician for a list of other tests to help you decide which test is best for you based on your needs.

Being prepared is the greatest method to deal with potential problems. Knowing whether or not your kid is healthy is the first step in preparing for your life together. The triple marker test will assist you in preparing for and ruling out potential difficulties impacting your child’s health and wellbeing. So plan ahead of time for this and another required testing, and enjoy a safe pregnancy!

What conditions can the Triple Marker Test detect?

This test can aid in the detection of genetic abnormalities like Down syndrome, Trisomy 18 syndrome and neural tube defects, prenatal/fetal infections or multiple pregnancies. If your AFP levels are high, your doctor will most likely conduct a thorough ultrasound to look for neural tube problems in the fetal skull and spine.

How much does the Triple Marker Test cost?*

The triple marker test is predicted to cost between INR 1250 and 4200.

*Disclaimer: The value varies based on location, time, and your preferred lab partner.

How long does it take to get the results for the Triple Marker Test?

You can expect to get the results for the Triple Marker Test test within 24 to 48 hours after the sample is collected. However, in certain cases, depending on the location, medical advice, and preferred lab partner, it may take longer.

What do abnormal Triple Marker Test results indicate?

An abnormal test may indicate the presence of multiple pregnancies or certain genetic anomalies in the baby like Down syndrome, Trisomy 18 or neural tube defects. If the index of suspicion is high, your doctor will most likely order additional testing or refer you to a specialist. An ultrasound exam is frequently the initial step. This examination helps determine the baby’s age and examine the brain, spinal cord, kidneys, and heart for any issues. Amniocentesis is another test that you could have. This test examines the fluid surrounding the infant. The findings of these tests will assist your doctor in determining whether or not your baby has a condition.

Disclaimer: Please consult with your doctor for interpreting the test reports.

Is Triple Marker a definitive test?

The triple marker test is not a definitive step as its main purpose is screening. It is critical to understand what a screening test is in order to feel at ease while taking one. A screening test is not used to make a diagnosis. It examines a number of data, such as age, ethnicity, blood test results, and so on, before indicating a risk factor for the presence of specific anomalies. A screening test is not conclusive in terms of pinpointing a specific problem; rather, it only aids in determining whether additional tests are required to determine a specific ailment or problem.

How to read the Triple Marker Test report?

The triple marker test is just a predictor or estimate of the likelihood of various genetic illnesses. The test can also be used to identify and recognize multiple birth scenarios. It indicates whether additional and deeper testing is required.

If the test results are good, the doctor will recommend additional amniocentesis and ultrasound testing for a more in-depth probe. The test results may or may not be accurate.

The AFP count from the amniocentesis result is taken into account. If the count remains low, you will be asked to undergo uterine ultrasound testing. Through fetal spine and skull examination, this test provides the gynecologist with an indication of possible genetic problems. Ultrasound can also detect the presence of numerous fetuses as well as their ages.

Greater AFP levels in the triple marker test suggest the probability of brain abnormalities. The typical AFP levels observed in women under the age of 35 range from 1.38 to 187.00 IU/ml. According to studies, the levels of beta-hCG range from 1.06 to 315 ng/ml.

The usual level for unconjugated estriol (uE3) ranges from 0.25 to 28.5.

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Why to book a Triple Marker Test?

A triple marker test can detect pregnancy problems and the existence of multiple fetuses. A triple marker screen test is especially effective for women over the age of 35. The main advantage of this test is that it detects birth problems in the infant and allows a pregnant woman to plan ahead of time for them. Among these genetic illnesses and anomalies are:

Trisomy 18, often known as Edward’s syndrome, is a chromosomal anomaly.
Down syndrome is a condition in which there is extra genetic material from chromosome 21 in the cell.
Neural tube defects are congenital disorders that affect the brain, spine, and spinal cord.

Triple Marker Test at home – how does it work?

The Triple Marker Test is just like any other blood test. A lab technician visits your home when you book your tests through the MFine app. The lab technician first cleans the arm and then inserts a syringe into a vein. The required amount of blood is then taken into a vial. The lab technician then removes the needle and places cotton wool or a bandage over the prick.

Are there any risks involved with the Triple Marker Test?

This test has no known adverse effects. Because the amount of blood drawn is so small, even the loss of blood is insignificant in terms of the mother’s health.

What can affect the results for the Triple Marker Test?

The triple marker test findings indicate the chance of a newborn having a genetic disease. The outcomes, however, are determined by the following factors:

The pregnant woman’s age
Ethnicity
Weight of a pregnant woman
Whether she is expecting a single child or multiple children
How far along in her pregnancy she is

After you have this test, your OB/GYN will review the results and let you know whether they are negative or positive. If the results of this test are false positive or she does not find a normal number for the triple marker test, your doctor may recommend additional tests.

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Frequently asked questions | FAQs

Does MFine provide the interpretation for the results along with the reports?

Yes, MFine provides the interpretation for the result along with the reports. You can also avail a free medical consultation with a doctor to understand your reports accurately. The doctor will also advise and prescribe medicines, if required, based on the results.

How can I download my Triple Marker Test report?

Login to MFine
Go to your profile
Click on Attachment and Reports
Click on Lab Report
Download the report

Are there any discount offers running on the Triple Marker Test?

Usually you can avail up to a 50% discount on lab tests through MFine. However, the discount and test price may vary based on lab partner and location.

Who is eligible to take this test?

This test is usually offered to all pregnant women and also highly indicated in pregnant women aged 35 and above who have a medical/family history of problematic pregnancies and lifestyle illnesses.

What Is the Difference Between a Double Marker Test and a Triple Marker Test?

The goal of double marker and triple marker tests is the same, but the test components and timing vary.

What Happens If the Triple Marker Test Is Positive?

This test is most commonly used to place an individual in one of the risk groups. Because the accuracy level is less than 80%, with 5% false positive cases, most Doctors run additional screening to confirm the results. Other tests that are advised are chorionic villus sampling and amniocentesis in addition to ultrasound scan.

How Reliable Is the Triple Marker Test?

The results of this test are based on standardized data and statistical estimates. Thus, accuracy ranges between 60 and 70%, with a 5% false-positive rate. However, other characteristics such as LMP, body weight, ultrasound scan, age, genetic problem history, and so on can help to increase the test’s accuracy.

Is a triple marker test required?

The triple marker screening is performed as a blood test. It is prescribed for women between the ages of 15 and 20 weeks pregnant.

Disclaimer: The content is uniquely informative and is meant for educational use. Kindly use the content only in consultation with an appropriate certified or registered healthcare provider.